Metabolomic CSI: high resolution lipidomic profiling of fingerprints using TD-SICRIT-MS and bioinformatics pipeline

This study shows the capabilities of the TD-SICRIT-MS and how they can be utilized in the world of metabolomics and lipidomics, with the full potential of such a study being realized through the combination of chemistry and computation.

With such a device and pipeline, you can go beyond the conventional forensic uses, without imaging or sample prep or only one main mechanism of ionization or significant matrix effects. This allows you to extend the range of ionizable metabolites, and in turn, expanding the level of features that are possible to visualize, to derive a clear chemical profile of a biological matrix, like a fingerprint, without worrying about sample prep destroying valuable metabolomic information or that the matrix effect will fully suppress the desired outcome. Furthermore, you can take this expansive list of features and with a simple database pipeline for feature filtering, you can focus in on those features that have potential biological significance.