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Developing a scalable metals removal process using metal scavengers
This application note demonstrates the practical application of metal scavenging in the removal of palladium from a model active pharmaceutical ingredient (API).

Metal mitigation, extractables and regulatory perspectives
Metal scavengers were first investigated for inherent metals content by ICP analysis methods. Then, these scavengers were extracted in a range of common solvents in order to show extractable/leachable levels. Lastly, an example metal scavenging mitigation step is demonstrated, looking at the corresponding API mass yield, purity and also metals data.

Biotage metal scavenger user guide
This user guide gives useful information on the Biotage metal scavengers, including: case studies, methods and advantages of the metal scavengers. It has selection guides to help the user choose the right product for their needs.

Biotage ISOLUTE Si-TMT metal scavenger
The Biotage ISOLUTE Si-TMT is the silica bound equivalent of 2,4,6-trimer- captotriazine (TMT). Si-TMT has been shown to efficiently scavenge residual palladium from palladium-catalyzed reactions. The function group in Si-TMT is attached to a bioanalytical grade silica platform, thus the use of this material does not introduce impurities to the reaction system. There are numerous advantages of functionalized Isolute Silica.

Biotage metal scavenging toolkit
The Biotage metal scavenging toolkit is an essential tool that can enable you to quickly and efficiently find the right metal scavenger for your application. Containing protocols, guidance and recommendations for working in batch mode or passing solutions through a fixed bed, this all in one kit showcases the metal scavengers and provides practical information on how to use the metal scavengers in your application for the best results.

Biotage ISOLUTE Si-Thiol metal scavenger
The Biotage ISOLUTE Si-Thiol is the silica-bound equivalent of 1-propane-thiol which is primarily used in the pharmaceutical industry as a metal scavenger for metals such as Pd, Pt, Cu, Hg, Ag and Pb, but it can also be useful for covalent scavenging of alkyl, benzyl and allyl halides as well as a variety of other electrophiles including acid chlorides and isocyanates.

Biotage ISOLUTE Si-Propylsulfonic Acid (SCX-2) metal scavenger
The Biotage ISOLUTE Si-Propylsulfonic Acid (SCX-2) belongs to a class of strong supported acids. As a bound sulfonic acid, it has a natural propensity to bind alkali and some transition metal group metals, which means that it can be used as a scavenger for metals with a +I or +II oxidation state, such as Na, K, Li, also Pd, Rh, and Ru. SCX-2 is typically used as a metal scavenger when the target product is not basic, to avoid the obvious acid/ base product binding interactions with the scavenger.

ASI PrimeLine infusion pump
ASI 576 infusion syringe pump is for mass spectrometer target analyte tuning; ion suppression tests and matrix addition. The pump can be used to inject either sample or wash solvent into a postcolumn, medium pressure fluidic system via integrated selector valve.

ASI PrimeLine syringe pumps
ASI Model 576 syringe pumps outperformed competitors in head-to-head engineering trials. Flow precision, was closed as the critical evaluation metric by an independent engineering team. ASI was best-in-class for low flow (uL/min.) for pressures up to 9,000 PSI. Applications requiring such high precision include: HPLC, LCMS, sampling systems, metering liquids and sample preparation.

ASI HPLC and UHPLC columns filters
ASI HPLC and UHPLC columns filters provide economical protection from the harmful effects of sample and mobile phase particulates on modern UHPLC and other high resolution HPLC columns.

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