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Extraction of nicotine and metabolites from urine, serum, plasma and whole blood using ISOLUTE SLE+ prior to LC-MS/MS analysis
This application note describes a SLE protocol for the extraction of nicotine, cotinine, 3-OH-cotinine, nornicotine, norcotinine and anabasine from urine, serum, plasma and whole blood using ISOLUTE SLE+ plates with LC-MS/MS detection.

Extraction of synthetic cannabinoids (SPICE) from oral fluid using ISOLUTE SLE+ 96-well plates and columns prior to LC-MS/MS
This application note describes the extraction of a range of SPICE drugs and metabolites from neat oral fluid and oral fluid from a commercial collection kit using ISOLUTE SLE+ in both 96-well plate and column formats.

Extraction of acrylamide from coffee using ISOLUTE SLE+ prior to LC-MS/MS analysis
The method described in this application note achieves high recoveries of acrylamide in coffee.

Extraction of phthalates in commercial milk products using ISOLUTE SLE+ Supported Liquid Extraction columns prior to LC-(+) APCI-MS/MS analysis
This application note describes a novel sample cleanup strategy to address the complex matrix effects associated with commercial milk product variables while maintaining adequate analyte recovery and repeatability.

Extraction of cocaine and metabolites from oral fluid using ISOLUTE SLE+ prior to GC-MS analysis
This application note describes the extraction of cocaine and a range of cocaine metabolites from spiked oral fluid collected with the Quantisal oral collection device prior to GC-MS.