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Extraction of benzodiazepines from whole blood using ISOLUTE SLE+ prior to GC/MS analysis
ISOLUTE SLE+ columns with 1 mL sample capacity are used to extract whole blood samples following a straightforward sample dilution. No protein precipitation or other pre-treatment is required prior to sample loading.

Extraction of buprenorphine and norbuprenorphine from whole blood using ISOLUTE SLE+ Supported Liquid Extraction prior to LC-MS/MS analysis
ISOLUTE SLE+ Supported Liquid Extraction products offer an efficient alternative to traditional liquid-liquid extraction for bioanalytical sample preparation, providing high analyte recoveries, no emulsion formation and significantly reduced sample preparation time.

How to process ISOLUTE SLE+ plates and columns with Pressure+ 96 & 48 positive pressure manifolds
ISOLUTE SLE+ Supported Liquid Extraction plates and columns offer an efficient alternative to traditional liquid-liquid extraction (LLE) for bioanalytical sample preparation, providing high analyte recoveries, no emulsion formation and greatly matrix effects associated with biofluid analysis.

Biotage EVOLUTE advanced polymeric sorbents SPE columns and plates

EVOLUTE EXPRESS sample preparation products are advanced water-wettable polymer-based sorbents for extracting drugs from biological fluids. Developed specifically for analyte quantification by LC-MS/MS, EVOLUTE sorbents provide a highly effective solution to the problems of ion suppression and matrix effects from dirty extracts. These high performance products allow scientists to use generic methodologies to reduce method development time while producing clean extracts for a wide range of compounds.

EVOLUTE EXPRESS represents a leap forward in high throughput solid phase extraction. The EVOLUTE EXPRESS range of SPE columns and 96-well plates combine powerful EVOLUTE sorbent chemistry with innovative features that enhance productivity. With improved flow-through characteristics and by eliminating the need for conditioning and equilibration, samples can be prepared much faster using the simplified Load-Wash-Elute procedure

Biotage ISOLUTE SPE columns and 96-well plates
ISOLUTE Solid Phase Extraction products are a range of leading quality SPE columns and 96-well plates, packed with a variety of ISOLUTE non-polar, mixed-mode, polar and ion exchange sorbents. Quality controlled sorbent chemistry, particle size distribution, component purity and manufacturing procedures mean that ISOLUTE SPE products perform reliably time after time. From biological fluids to wastewater samples, the wide range of sorbents and formats along with the wealth of technical and application support available from Biotage mean you can develop robust, reproducible SPE methods giving high analyte recovery and clean extracts.

Biotage ISOLUTE SLE+ Supported Liquid Extraction columns and plates
ISOLUTE SLE+ Supported Liquid Extraction plates and columns are designed to provide stress free extraction of analytes from biological fluids, with high analyte recoveries, and clean, protein and phospholipid free extracts. Methods are easy to develop, and automation is simple.

Acidic, basic and neutral drug screen of hydrolyzed urine using supported liquid extraction prior to LC-MS/MS analysis
ISOLUTE SLE+ is used to quickly screen a panel of drugs from a small amount of urine (100 uL).

Extraction of estrone and estradiol from human serum using ISOLUTE SLE+ prior to HPLC-MS/MS
This application note describes a simple supported liquid extraction method for extraction of estrone and estradiol from human serum. An analytical HPLC-MS/MS method that avoids the use of derivatization or fluoride adduct stabilization (two approaches often used to enhance method sensitivity) is used.

Extraction of illicit drugs and pesticides from liver tissue using ISOLUTE SLE+ prior to GC/MS analysis
This application note describes the extraction of a broad range of analytes from liver tissue matrix prior to GC/MS analysis using ISOLUTE SLE+ supported liquid extraction columns. A protocol has been developed that allows the simultaneous extraction of various drugs of abuse classes: amphetamines, barbiturates, benzodiazepines, cocaine, ketamine, THC.

Extraction of amphetamines and analogues from hair using ISOLUTE SLE+ prior to GC/MS analysis
This application note describes the extraction of amphetamine and amphetamine-style compounds from hair matrix prior to GC/MS analysis following bead homogenization. An effective and efficient ISOLUTE SLE+ protocol optimized for 1 mL capacity formats is detailed.

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